Biostatistics Study NotesFrom concepts and derivations to interpretation

CHAPTER 02 · TOPIC 03

Normal Distribution and Z Scores

Study the normal distribution, standardization, Z scores, cumulative probabilities, and links to other sampling distributions.

On this page
  1. Normal distribution shape
  2. Standard normal distribution and Z-score
  3. Find probability from density curve
  4. Cumulative distribution function and Z table
  5. Why is the normal distribution important?
  6. How are the normal, χ², t, and F distributions connected?

The normal distribution is a continuous probability distribution and is also called the Gaussian distribution because its density curve is symmetrical and bell-shaped. It is one of the most important distributions in statistics, and many measurements, sample statistics, and statistical methods use it directly or indirectly.

Normal distribution shape#

A normal distribution is determined by mean μ and variance σ². The mean determines the center of the curve, and the standard deviation σ determines the spread. The larger σ is, the wider and lower the curve, and the smaller σ is, the narrower and higher the curve.

  • Symmetrical around the average μ
  • The mean, median, and mode are in the same center
  • Both ends approach the x axis but do not intersect
  • The total area under the density curve is 1
  • The interval probability is the area under the curve for that interval
Normal distribution notationXN(μ,σ2)X\sim N(\mu,\sigma^2)
probability density functionf(x)=1σ2πexp ⁣[(xμ)22σ2]f(x)=\frac{1}{\sigma\sqrt{2\pi}}\exp\!\left[-\frac{(x-\mu)^2}{2\sigma^2}\right]
symbolmeaning
XContinuous random variable with normal distribution
xone possible value of X
μpopulation mean. determine the center of the distribution
σPopulation standard deviation. determine the width of the distribution
σ²population variance
f(x)Probability density at x. Not a probability of 1 point
π、exppi and exponential function

Standard normal distribution and Z-score#

A normal distribution with different mean and standard deviation has the problem that it is difficult to share a single probability table. By subtracting the mean from X and dividing by the standard deviation, you can convert it to a standard normal variable Z. This is called standardization.

standardizationZ=XμσZ=\frac{X-\mu}{\sigma}
standard normal distributionZN(0,1)Z\sim N(0,1)

The Z-score represents how many standard deviations the observed value is from the mean. If z=1.5, it is 1.5 standard deviations above the mean, and if z=−2, it is 2 standard deviations below. Standardization only changes the scale, not the relative position of the values ​​or the shape of the distribution.

symbolmeaning
Z、zStandard normal variables and their realizations
XRandom variable before standardization
μpopulation mean of X
σpopulation standard deviation of X
N(0,1)Standard normal distribution with mean 0 and variance 1

Find probability from density curve#

Since the normal distribution is continuous, the probability of one point is 0. What is actually calculated is the area under the curve of the interval. P(a≤X≤b) represents the probability that X falls between a and b.

Probability of 1 pointP(X=x)=0P(X=x)=0
interval probabilityP(aXb)=abf(x)dxP(a\le X\le b)=\int_a^b f(x)\,dx
total areaf(x)dx=1\int_{-\infty}^{\infty}f(x)\,dx=1

Cumulative distribution function and Z table#

The cumulative distribution function of the standard normal distribution is usually written as Φ(z), and it represents the left-sided probability that Z is less than or equal to z. Traditional Z tables often show this cumulative area, but you need to check which table shows the area on the left, right, or from the average to z.

left side cumulative probabilityΦ(z)=P(Zz)\Phi(z)=P(Z\le z)
symmetrical relationshipΦ(z)=1Φ(z)\Phi(z)=1-\Phi(-z)
right tail probabilityP(Z>z)=1Φ(z)P(Z>z)=1-\Phi(z)
z valueLeft cumulative probability Φ(z)interpretation
−∞0No area on the left
00.5000Center of symmetry. half left and right
1.645Approximately 0.9500Approximately 5% right hem
1.960Approximately 0.9750The right hem is approximately 2.5%. -1.96 to 1.96 is about 95%
+∞1including total area

Why is the normal distribution important?#

Some biometric measurements can approach a normal distribution under certain populations and conditions. However, you should not assume normality just because the data is continuous. Judgments will be made based on research background, graphs, and diagnostic methods.

  • Many sample statistics approximate a normal distribution under appropriate conditions and with a large enough sample size.
  • Binomial distribution etc. can be approximated by normal distribution if the conditions are met.
  • Normal theory or its approximations are often used in confidence intervals, hypothesis testing, and regression analysis.

How are the normal, χ², t, and F distributions connected?#

χ², t, and F are not independent curves. Starting from independent standard normal variables, they can be constructed through squaring, addition, division, and ratios. This relationship is the common basis for understanding variance estimation, t-tests, chi-square tests, and ANOVA.

Sum of squares: χ² distributionU=i=1νZi2χν2U=\sum_{i=1}^{\nu}Z_i^2\sim\chi^2_{\nu}
Standard normal divided by estimated standard error: t distributionT=ZU/νtνT=\frac{Z}{\sqrt{U/\nu}}\sim t_{\nu}
Ratio of two standardized variations: F distributionF=U1/ν1U2/ν2Fν1,ν2F=\frac{U_1/\nu_1}{U_2/\nu_2}\sim F_{\nu_1,\nu_2}
symbolmeaning
Z、Zᵢstandard normal variables that are independent of each other
U、U₁、U₂Random variable following a χ² distribution
ν、ν₁、ν₂Degree of freedom. Greek letter ν is pronounced nu
TRandom variable that follows the t distribution
FRandom variable following F distribution